Paracchini et al. evaluated the use of archival Papanicolaou test smears as a source of tissue for early detection of ovarian cancer. The authors obtained DNA from these samples from which they performed shallow whole-genome sequencing and identified high copy number profile abnormality (CPA) correlated to ovarian cancer development. They created an early ovarian cancer test (EVA), providing a proof of principle for using Pap smears and CPA for early diagnosis of ovarian cancer.