According to the NCI website, selinexor is an orally available, small molecule inhibitor of CRM1 (chromosome region maintenance 1 protein, exportin 1 or XPO1), with potential antineoplastic activity. Check for active clinical trials using this agent. (NCI Thesaurus)
Indikation gemäss NCI Eebsite:
- Multiple myeloma that has relapsed (come back) or is refractory (does not respond to treatment). It is used with dexamethasone in adults who have received at least four previous treatments that included at least two proteasome inhibitors, at least two immunomodulating agents, and an anti-CD38 monoclonal antibody.
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