MGD019 bispecific PD-1 x CTLA-4 DART®
According to the NCI website, anti-PD-1/anti-CTLA-4 DART protein MGD019 is a hinge stabilized immunoglobulin G4 (IgG4) tetravalent bispecific antibody-like protein directed against the human negative immunoregulatory checkpoint receptors programmed cell death protein 1 (PD-1; PDCD1; CD279) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. (NCI Thesaurus)
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