According to the NCI website axicabtagene ciloleucel is a preparation of autologous peripheral blood T-lymphocytes (PBTL). Check for active clinical trials using this agent.

Indikationen gemäss Compendium.ch®

YESCARTA ist eine gegen CD19 gerichtete, genetisch modifizierte autologe T-Zell-Immuntherapie und wird angewendet bei erwachsenen Patienten zur Behandlung von rezidiviertem oder refraktärem diffus grosszelligem B-Zell-Lymphom (DLBCL) und primär mediastinalem grosszelligem B-Zell-Lymphom (PMBCL) nach zwei oder mehr systemischen Therapielinien.

Link zur Fachinformation von Compendium.ch®:

Medikamenteniformation: Für den Arzt

According to the NCI website Axicabtagene ciloleucel is approved to treat:

• B-cell non-Hodgkin lymphoma(NHL), including the following types:
  • Diffuse large B-cell lymphoma (DLBCL).
  • DLBCL in patients who had follicular lymphoma.
  • Primary mediastinal large B-cell lymphoma.
  • High-grade B-cell lymphoma.

It is used in adults whose disease has relapsed or has not gotten better after at least two other types of systemic treatment.

Axicabtagene ciloleucel is also being studied in the treatment of other types of cancer.

More Information in English:

Link to Drug Information Portal, a service of the U.S. National Library of Medicine, National Institutes of Health
Link to National Cancer Institute
Link zu Wiki

Link zu PharmaWiki
Link to Physicians Desk Reference (PDR)
Link to European Medicines Agency (EMEA)
Info for Patients presented by Scott Hamilton from Chemocare.com