According to the NCI website, Magrolimab is a humanized monoclonal antibody targeting the human cell surface antigen CD47, with potential immunostimulating and antineoplastic activities. Check for active clinical trials using this agent. (NCI Thesaurus)

More Information in English:

Link to Drug Information Portal, a service of the U.S. National Library of Medicine, National Institutes of Health
Link to National Cancer Institute

According to the NCI website, margetuximab is a Fc-domain optimized IgG monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2) with potential immunomodulating and antineoplastic activities. Check for active clinical trials using this agent. (NCI Thesaurus)

More Information in English:

Link to Drug Information Portal, a service of the U.S. National Library of Medicine, National Institutes of Health
Link to National Cancer Institute

Wiki

According to the NCI website, MBG453 (Anti-TIM-3 Monoclonal Antibody MBG453) is an inhibitor of the inhibitory T-cell receptor T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3; hepatitis A virus cellular receptor 2; HAVCR2), with potential immune checkpoint inhibitory and antineoplastic activities.

Link to National Cancer Institute

Wiki

Relationships with other NCI Thesaurus Concepts

According to the NCI the hydrochloride salt of mechlorethamine, is a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities.

Indikationen/Anwendungsmöglichkeiten gemäss Chemocare.com:
As part of combination regimens in treatment of Hodgkin's disease, non-Hodgkin's lymphoma.
As palliative chemotherapy in lung and breast cancers.
As a lotion to skin lesions of mycosis fungoides (cutaneous T-cell lymphoma).

According to the NCI website Mimicking the action of progesterone, megestrol binds to and activates nuclear progesterone receptors (PRs) in the reproductive system and pituitary.

IIndikationen/Anwendungsmöglichkeiten gemäss folgendem Link (Medien Plus):
Megestrol tablets are used to relieve the symptoms and reduce the suffering caused by advanced breast cancer and advanced endometrial cancer (cancer that begins in the lining of the uterus). Megestrol suspension is used to treat loss of appetite, malnutrition, and severe weight loss in patients with acquired immunodeficiency syndrome (AIDS). Megestrol should not be used to prevent loss of appetite and severe weight loss in patients who have not yet developed this condition. Megestrol is a man-made version of the human hormone progesterone. It treats breast cancer and endometrial cancer by affecting female hormones involved in cancer growth. It increases weight gain by increasing appetite.

Link to Drug Information Portal, a service of the U.S. National Library of Medicine, National Institutes of Health

Link to MedlinePlus, a service of the U.S. National Library of Medicine, National Institutes of Health
Link to National Cancer Institute
Link zu Wiki
Link zu PharmaWiki
Link to Physicians Desk Reference (PDR)
Info for Patients presented by Scott Hamilton from Chemocare.com

According to the NCI website, the MEK inhibitor MEK162 isan orally available inhibitor of mitogen-activated protein kinase kinases 1 and 2 (MEK1/2) with potential antineoplastic activity.

Link to Drug Information Portal, a service of the U.S. National Library of Medicine, National Institutes of Health

Link to National Cancer Institute

Mek inhibitors

Indikationen/Anwendungsmöglichkeiten gemäss Arzneimittel-Kompendium der Schweiz®:

Multiples Myelom.

Fortgeschrittenes Ovarialkarzinom.

Mammakarzinom.

Alkeran kann in Mono- oder Kombinationstherapie beim fortgeschrittenen Mamma-Karzinom eine therapeutische Wirkung haben.

Regionale arterielle Perfusion bei lokalisiertem, malignem Melanom oder Weichteilsarkom der Extremitäten.

Polycythaemia rubra vera: Alkeran hat sich bei einigen Patienten als wirksam erwiesen.

Hochdosiertes Alkeran i.v. als Vorbereitung zur hämopoetischen Stammzell-Transplantation wird entweder allein oder in Kombination mit Radiotherapie und/oder mit anderen zytostatischen Mitteln angewendet zur Konsolidierung des mit konventioneller Behandlung erreichten Resultates bei Neuroblastom bei Kindern und Jugendlichen und bei Multiplem Myelom.

Link to Drug Information Portal, a service of the U.S. National Library of Medicine, National Institutes of Health
Link to MedlinePlus, a service of the U.S. National Library of Medicine, National Institutes of Health
Link to National Cancer Institute
Link to Wikipedia
Link zu PharmaWiki
Link to Physicians Desk Reference (PDR)
Link zur Fachinformation des Arzneimittel-Kompendium der Schweiz
Info for Patients presented by Scott Hamilton from Chemocare.com

According to the NCI mercaptopurine is a thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities.

Indikationen/Anwendungsmöglichkeiten gemäss Arzneimittel-Kompendium der Schweiz®:

Zur Behandlung in Kombination mit LHRH Agonisten und Prednison oder Prednisolon bei Patienten mit fortgeschrittenem metastasierenden Prostatakarzinom bei Progredienz nach Behandlung mit Docetaxel.c

Link to Drug Information Portal
Link to MedlinePlus
Link to National Cancer Institute
Link zu Wiki
Link zu PharmaWiki
Link to Physicians Desk Reference (PDR)
Link to European Medicines Agency (EMEA)
Link zur Fachinformation des Arzneimittel-Kompendium der Schweiz
Info for Patients presented by Scott Hamilton from Chemocare.com

According to the NCI, methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities.

Indikationen/Anwendungsmöglichkeiten gemäss Arzneimittel-Kompendium der Schweiz®:

Behandlung hämatologischer Neoplasien wie akute lymphatische und myeloische Leukämie und Non-Hodgkin-Lymphom sowie solider Tumoren wie Mammakarzinom, Bronchialkarzinom, maligne Kopf- und Halstumoren, Osteosarkom, Chorionkarzinom und andere trophoblastische Tumoren, Blasenkarzinom.
Behandlung von Autoimmunerkrankungen wie z.B. rheumatoide Arthritis.
Behandlung schwerer Fälle unkontrollierbarer Psoriasis, welche gegenüber konventioneller Therapie resistent sind.

Link to Drug Information Portal
Link to MedlinePlus
Link to National Cancer Institute
Link zu Wiki
Link zu PharmaWiki
Link to Physicians Desk Reference (PDR)
Link zur Fachinformation des Arzneimittel-Kompendium der Schweiz
Info for Patients presented by Scott Hamilton from Chemocare.com

Zytostatikum

According to the NCI website, anti-PD-1/anti-CTLA-4 DART protein MGD019 is a hinge stabilized immunoglobulin G4 (IgG4) tetravalent bispecific antibody-like protein directed against the human negative immunoregulatory checkpoint receptors programmed cell death protein 1 (PD-1; PDCD1; CD279) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. (NCI Thesaurus)

More Information in English:

Inxight: Drugs (NIH)

AdisInsight
Link to National Cancer Institute

According to the NCI website, Mirvetuximab soravtansine is an immunoconjugate consisting of the humanized monoclonal antibody M9346A against folate receptor 1 (FOLR1) conjugated, via the disulfide-containing cleavable linker sulfo-SPDB, to the cytotoxic maytansinoid DM4, with potential antineoplastic activity.  Check for active clinical trials using this agent. (NCI Thesaurus)

More Information in English:

Link to Drug Information Portal, a service of the U.S. National Library of Medicine, National Institutes of Health
Link to National Cancer Institute

Wiki
Link to European Medicines Agency (EMEA)

According to the NCI, mitomycin C is a methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species.

Indikationen/Anwendungsmöglichkeiten gemäss Medlineplus Druginfo:
This medication is used to treat adenocarcinoma of the stomach and pancreas.

Link to Drug Information Portal
Link to MedlinePlus
Link to National Cancer Institute
Link zu Wiki
Link zu PharmaWiki
Link to Physicians Desk Reference (PDR)
Info for Patients presented by Scott Hamilton from Chemocare.com

Chemotherapy

ccording to the NCI, mitotane is a synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties.

Indikationen/Anwendungsmöglichkeiten gemäss Arzneimittel-Kompendium der Schweiz®:

Link to Drug Information Portal
Link to MedlinePlus
Link to National Cancer Institute
Link zu Wiki
Link zu PharmaWiki
Link to Physicians Desk Reference (PDR)
Link to European Medicines Agency (EMEA)
Link zur Fachinformation des Arzneimittel-Kompendium der Schweiz

Zytostatikum

According to the NCI website, Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair.

Indikationen/Anwendungsmöglichkeiten gemäss Arzneimittel-Kompendium der Schweiz®:

Metastasierendes Mamma-Karzinom.
Non-Hodgkin-Lymphome.
Akute Leukämie der Erwachsenen.
Blastenschub der chronischen myeloischen Leukämie.
Hepatozelluläres Karzinom.
Palliative Therapie des fortgeschrittenen hormonrefraktären Prostata-Karzinoms mit Schmerzzuständen, in Kombination mit niedrig dosierten Steroiden (Prednison).
Mitoxantron Sandoz ist indiziert für die Behandlung von gehfähigen Patienten mit Multipler Sklerose bei rasch progredientem Verlauf und Versagen oder Unverträglichkeit einer Vortherapie mit Immunmodulatoren. Die rasche Progression kann sich entweder als kontinuierliche Zunahme neurologischer Defizite mit und ohne überlagerte Schübe (sekundär progredienter Verlauf) oder als rasch akkumulierende Defizite aufgrund sich unvollständig zurückbildender Schübe (schubförmiger Verlauf mit Residuen) äussern.

Link to MedlinePlus, a service of the U.S. National Library of Medicine, National Institutes of Health
Link to National Cancer Institute
Link zu Wiki
Link zu PharmaWiki
Link to Physicians Desk Reference (PDR)
Link zur Fachinformation des Arzneimittel-Kompendium der Schweiz
Info for Patients presented by Scott Hamilton from Chemocare.com

Zytostatikum

According to the NCI website, the anti-ILT4 monoclonal antibody MK-4830 is a human monoclonal antibody. Check for active clinical trials using this agent. (NCI Thesaurus)

More Information in English:

AdisInsight
Link to National Cancer Institute