SAN ANTONIO BREAST CANCER SYMPOSIUM
December 7-11, 2021
All Sessions
- General Session 1
- General Session 2
- General Session 3
- General Session 4
General Session 1
Publication Number: GS1-00:
Giampaolo Bianchini, Xiao Qian Wang, Esther Danenberg, et al.
Overall, the authors were able to show in their large, randomized study that IMC is feasible and provides independent predictive information on the benefit of immune checkpoint inhibitors for PD-L1, TILs and gene expression profiles.
Publication Number: GS1-01:
Peter Schmid, Javier Cortes, Rebecca Dent, et al.
The authors conclude that the EFS sensitivity analyzes revealed a robust and generally consistent treatment benefit of neoadjuvant pembro + chemotherapy followed by adjuvant pembro across a wide range of patient subgroups in previously untreated, non-metastatic triple-negative breast cancer.
Publication Number: GS1-02
Javier Cortes, David W. Cescon, Hope S. Rugo, et al.
The authors conclude that the study shows that CPS ≥ 10 is a reasonable cut-off to define the patient population with metastatic triple negative breast cancer who could benefit from Pembro + chemotherapy.
Publication Number: GS1-05
Ian Krop, Dejan Juric, Toshio Shimizu, et al.
The authors conclude that Dato-DXd has shown promise in antitumor activity in patients with previously treated advanced / metastatic triple negative breast cancer. The security profile is manageable.
Publication Number: GS1-06
Binghe Xu, Qingyuan Zhang, Xichun Hu, et al.
The authors conclude that compared with exemestane monotherapy, entinostat plus exemestane significantly improved progression-free survival in HR-positive, HER2-negative breast cancer that had progressed after previous endocrine therapy. The combination was generally tolerated and may offer important clinical benefit in these patients.
Publication Number: GS1-07
Michael Gnant, Amylou C Dueck, Sophie Frantal, et al.
The authors conclude that this analysis of the PALLAS study shows that adding 2 years of palbociclib to ongoing adjuvant endocrine therapy did not improve survival endpoints for patients with HR + / HER2-eBC stage II-III.
Publication Number: GS1-08
Pamela J. Goodwin, Bingshu E Chen, Karen A Gelmon, et al.
The authors conclude that MET did not improve IDFS or other BC results and should not be used as an adjuvant treatment.
Publication Number: GS1-09
Inhibition of GPX4 induces preferential death of p53-mutant triple-negative breast cancer cells
William M Tahaney, Jing Qian, Reid Powell, et al.
With their studies, the authors provide the scientific basis for the further development of ferroptosis inducers for the targeted treatment of p53-mutated breast cancer. For more information see the abstract.
Publication Number: GS1-10
Fabrice André, Anthony Gonçalves, Thomas Filleron, et al.
SAFIR02/PI3K studies show that the clinical application of multigene sequencing must take place within a framework that determines whether it can lead to clinical action. Multigene sequencing identifies novel genomic changes associated with the development of metastases and drug resistance or sensitivity.
General Session 2
Publication Number: GS2-00.
Lisa Carey, Nadia Solovieff, Fabrice André, et al.
The authors' analysis confirmed the prognostic and predictive value of intrinsic subtype (PAM50 based) for OS. The addition of RIB to ET resulted in consistent OS benefit across all subtypes except for basal-like.
Publication Number: GS2-01.
Joyce O'Shaughnessy, Salomon M Stemmer, Howard A Burris, et al.
The study demonstrated with this prespecified exploratory analysis an OS benefit with RIB + LET independent of the site and number of metastatic lesions.
Publication Number: GS2-02.
Aditya Bardia, Patrick Neven, Guillermo Streich, et al.
The first oral SERD Elacestrant demonstrate a statistically significant and clinically meaningful improvement of PFS vs SOC. It was well tolerated and the authors conclude that the drug has the potential to become the new standard of care for pts with ER+/HER2- mBC.
Publication Number: GS2-04
Rosie Bradley, Jeremy Braybrooke, Richard Gray1, et al.
AI instead of tamoxifen reduces the risk of breast cancer recurrence by about 20 percent in premenopausal women with ovarian suppression. The authors conclude: "If the surprising lack of benefit in N4 + disease is an incidental finding, then the absolute benefit is greater for women with a higher absolute risk of recurrence."
Publication Number: GS2-05.
Meredith M Regan, Barbara A Walley, Gini F Fleming, et al.
After 13 years adjuvant E+OFS, as compared with T+OFS, shows a sustained reduction in the recurrence-risk, more consistent in HER2 negative patients and in those with high-risk disease features.
Publication Number: GS2-06
Jeremy Braybrooke, Rosie Bradley, Richard Gray, et al.
Anthracycline in addition to taxane chemotherapy reduced the risk of breast cancer recurrence by 18 percent compared to Taxane Mono.
Publication Number: GS2-07
Kevin M Kalinsky, William E Barlow, Julie R Gralow, et al.
Premenopausal patients with 1-3 + LN and RS <25 demonstrated a statistically significant improvement in DRFI with additional CT. A small proportion of the S1007 premenopausal participants underwent ovarian function suppression.
Publication Number: GS2-09.
Kirsten Kubler, Agostina Nardone, Shankara Anand, et al.
The authors describe a distinct and novel pathway of carcinogenesis in which tamoxifen acts as a driver event in the uterus and promotes tumor development in a mutation-independent manner.
Publication Number: GS2-10.
Romualdo Barroso-Sousa, Tianyu Li, Sangeetha Reddy, et al.
The authors conclude, that the study achieved the primary endpoint and demonstrated a confirmed ORR of 13.3%.
General Session 3
Publication Number: GS3-01
Sara Hurvitz, Sung-Bae Kim, Wei-Pang Chung, et al.
DESTINY-Breast03 is the first reported randomized phase 3 study comparing T-DXd with standard of care treatment. It met the primary endpoint and T-DXd demonstrated superior PFS over T-DM1 and T-DXd with a manageable safety profile. A consistent PFS and ORR benefit with T-DXd vs. T-DM1 was seen in all HER2 + metastatic breast cancer subgroups previously treated with trastuzumab and taxane, including patients with brain metastases.
Publication Number: GS3-02.
Binghe Xu, Min Yan, Fei Ma, et al.
Pyrotinib plus capecitabine demonstrated a statistically significant OS improvement compared with lapatinib plus capecitabine in HER2-positive MBC after trastuzumab and chemotherapy. According to the authors, this reaffirms pyrotinib plus capecitabine as an established treatment option in this patient population
Publication Number: GS3-03
Emanuela Ferraro, Alison Smith, Anton Safonov, et al.
PIK3CA-activating mutations detected by tumor sequencing and the lack of genomic ERBB2 amplification are associated with reduced progression-free survival in HP-based therapy. The clinical-genomic analysis of the mechanisms of resistance clearly identified changes in the MAPK signaling pathway as additional potential drivers of resistance to anti-HER2 therapy. The authors speculate that inhibiting the PI3K or MAPK signaling pathway in such tumors could be a new therapeutic strategy to expand the H / P utility.
Publication Number: GS3-05.
François-Clément Bidard, Anne-Claire Hardy-Bessard, Thomas Bachelot, et al.
PADA-1 reached its primary objective and demonstrates that targeting bESR1mut-associated resistance through a change in the endocrine partner of palbociclib is feasible and allows a doubling in the subsequent median PFS.
Publication Number: GS3-06.
Nicholas Turner, Claire Swift, Ben Jenkins, Lucy Kilburnet al.
The authors' findings have implications for future trial design, emphasizing the importance of early start of ctDNA testing, and more sensitive and/or more frequent ctDNA testing regimes.
Publication Number: GS3-07
Giampaolo Bianchini, Luca Malorni, Grazia Arpino, et al.
The authors demonstrated, that the pretreatment and early dynamics of the ctDNA (assessed by NGS) are promising prognostic and predictive biomarkers in patients with HR + / HER2-aBC treated first-line with ribociclib / letrozole.
Publication Number: GS3-09
Loss of ASXL1 tumor suppressor promotes resistance to CDK4/6 inhibitors in ER+ breast cancer
Dhivya R. Sudhan, Sumanta Chatterjee, Jiwoong Kim, et al.
CDK2 inhibitors can be a treatment approach for drug-resistant tumors. For more information please consult the abstract.
Publication Number: GS3-10
Charles Coombes, Sasha J Howell, Matthew G Krebs, et al.
Samuraciclib plus fulvestrant shows an acceptable safety profile with evidence of anti-tumor activity in advanced HR + BC after previous CDK4 / 6i therapy.
General Session 4
Publication Number: GS4-01.
Andrea V. Barrio, Giacomo Montagna, Varadan Sevilimedu, et al.
Black and Hispanic women had a higher incidence of BCRL development compared to Caucasian women, with Black race being the strongest predictor of BCRL development and of severe BCRL.
Publication Number: GS4-02.
Analysis of clinical outcomes and expression-based immune signatures by race in the I-SPY 2 trial
Beverly Kyalwazi, Christina Yau, Olufunmilayo Olopade, et al.
Among women with high-risk breast cancer, race does not affect subtype-specific response rates nor event-free survival. Hence, race is less likely than tumor biology to predict response. The decreased expression of immune signatures observed in Black or African American women with TNBC suggests possible differential sensitivity to immunotherapy plus combination chemotherapy.
Publication Number: GS4-03
Bernd Gerber, Angrit Stachs, Kristina Veselinovic, et al.
The authors conclude from the data that patients without SLNB benefited in terms of arm symptoms/function. There were no relevant differences in other QoL scales.
Publication Number: GS4-05
Damiano Gentile, Wolfgang Gatzemeier, Erika Barbieri, et al.
The OS rate in the standard and experimental arm was over 99 percent; The DFS rate is 96.8% and 95.9% in the standard and experimental arms, respectively. After a median of 36 months, there was only one axillary relapse in the experimental arm. Seven distant relapses were observed in both arms and four and three deaths in the standard and experimental arms, respectively.
Publication Number: GS4-06
Estimation of breast cancer overdiagnosis in a US breast screening cohort
Marc D Ryser, Jane Lange, Lurdes Inoue, et al.
Overdiagnosis of screen-detected cancers is less common than in studies with excessive incidence estimates and more common than estimates in previous modeling studies that did not consider indolent tumors.
Publication Number: GS4-07
Siri H Strand, Belén Rivero-Gutiérrez, Kathleen E Houlahan, et al.
Genomic profiling in two independent DCIS cohorts with longitudinal section results provides different DCIS stroma expression patterns and immune cell compositions. RNA expression profiles provide information about the underlying tumor biology associated with later iBEs in both cohorts. In doing so, they gain new insights into DCIS biology and guide the development of diagnostic strategies to prevent invasive progression.
Publication Number: GS4-08
Anton Safonov, Chai Bandlamudi, Paulino Tallón de Lara, et al.
The analysis of germline-somatic interactions revealed new associations relevant to breast cancer progression and treatment resistance. BRCA2 carriers have worse results than the first-line CDK4 / 6i-ET. This has potential implications for optimal first-line therapy and sequencing of CDK4 / 6i versus PARPi in this patient population.
Publication Number: GS4-09.
Patricia A Ganz, Hanna Bandos, Tanja Spanic, et al.
According to the authors, increased treatment-emergent symptoms with OL were small and resolved after treatment. QOL scores were similar and slowly improved during the 24 months after (neo) adjuvant chemotherapy.
Publication Number: GS4-10
Komal Jhaveri, Haeseong Park, James Waisman, et al.
Neratinib + fulvestrant + trastuzumab (N+F+T ) is a promising combination for patients with HR +, HER2-mutant MBC with prior exposure to CDK4 / 6 inhibitors. Neratinib + trastuzumab also showed encouraging activity on HER2 mutant TNBC. The first results from the randomized comparison of N + F + T vs. F + T vs. F in patients with HR +, HER2-mutated MBC (Simon stage 1 analysis) will be presented at the conference.