Startseite Kongressberichte & Archiv 2021 ASCO Annual Meeting Haematological Malignancies Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia

Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia

Jeff Porter Sharman, Miklos Egyed, Wojciech Jurczak, et al.
The study authors conclude that with a median follow-up of almost four years, the efficacy and safety of acalabrutinib  ± obinutuzumab and acalabrutinib monotherapy was maintained. There was an increase in CR since the interim analysis (from 21% to 27% [A+O] and from 7% to 11% [A]) and low rates of discontinuation.
Matthew J. Matasar, Marcelo Capra, Muhit Özcan, et al.
The study authors conclude that copanlisib + rituximab demonstrated superior efficacy compared to rituximab + placebo in patients with relapsed follicular (FL) or marginal zone lymphoma /MZL). The combination had a manageable safety profile, consistent with copanlisib and rituximab as monotherapy. According to the authors, copanlisib is the first PI3K inhibitor to be safely combined with rituximab in relapsed FL/MZL, representing a potential new therapeutic option. Clinical trial information: NCT02367040
Nilanjan Ghosh, Gilles A. Salles, Izidore S. Lossos, et al.
The study authors conclude that the triple combination is efficacious in patients with relapsed/refractory follicular lymphoma. The data from the final analysis suggest a potential for improved outcomes versus the Obinutuzumab-lenalidomide doublet. Clinical trial information: NCT02631577
Catherine S. Magid Diefenbach, Pau Abrisqueta, Eva Gonzalez-Barca, et al.
The study authors conclude that their study demonstrates a tolerable safety profile. Pola-R-Len shows promising activity in a difficult-to-treat R/R DLBCL population. This is particularly observed in patients achieving CR, a large proportion of whom remain in remission at the cutoff date. Clinical trial information: NCT02600897
Johannes Düll, Kami J. Maddocks, Eva Gonzalez-Barca, et al.
The study authors conclude that the combination with tafasitamab + lenalidomide followed by tafasitamab monotherapy provided durable responses in patients with R/R DLBCL not eligible for ASCT. A  manageable safety profile was observed. This indicates the potential of tafasitamab + lenalidomide in this patient population followed by extended tafasitamab monotherapy in achieving prolonged remission and survival benefit, especially at first relapse. Clinical trial information: NCT02399085
Jia Ruan, Jasmine M. Zain, Brett Palmer, et al.
The study authors provide the first demonstration that a chemo-free biologic combination of romidepsin and lenalidomide is a feasible and effective initial treatment for PTCL patients who are not candidates for cytotoxic chemotherapy. Clinical trial information: NCT02232516
Caron A. Jacobson, Julio C. Chavez, Alison Sehgal, et al.
The study authors conclude that axicabtagene ciloleucel showed in this population with high-risk disease with POD24 iNHL a high rate of durable responses in patients. Efficacy results, as well as safety and pharmacological profiles, appeared largely comparable between groups, except for the progression-free survival rates. Clinical trial information: NCT03105336
Bijal D. Shah, Caron A. Jacobson, Scott Solomon, et al.
The study authors conclude that PBCAR0191 has demonstrated dose and LD-dependent cell expansion kinetics with encouraging anti-tumor activity. They note, that host-versus-graft rejection may have a role in depth and durability of response. Finally, CR rates with this allogeneic, off-the-shelf CD19-targeting CAR-T product are preliminarily comparable to those observed with autologous CAR T in this population.  Clinical trial information: NCT03666000
Joshua W. Keegan, Frank Borriello, Stacey M. Fernandes, et al.
The study authors demonstrate for the first time that peripheral blood mononuclear cells from CLL patients can be converted into SUPLEXA cells (a 300-fold expansion of NK cells, CD8+ T cells, NKT cells, and TCRγδ T cells). This is achieved despite low numbers of normal immune cells at baseline and the known immunologic impairment present in CLL patients. The authors stress, that importantly, SUPLEXA cells derived from CLL patients acquire potent tumor killing activity that is indistinguishable from SUPLEXA cells prepared from NHVs. They conclude, that these findings support the feasibility of converting PBMCs from CLL patients with low percentages of NK and T cells into an autologous cellular therapy for cancer.
Michael Roost Clausen, Pieternella Lugtenburg, Martin Hutchings, et al.
The study authors conclude that with longer follow-up, subcutaneous epcoritamab - a CD20xCD3 bispecific antibody that induces T-cell–mediated killing of CD20–positive malignant B-cells - demonstrated substantial single-agent activity, inducing deep and durable clinically meaningful responses, with a consistent safety profile without severe (grade ≥3) CRS events, no febrile neutropenia, and limited neurotoxicity. Clinical trial information: NCT03625037
Carmelo Carlo-Stella, Martin Hutchings, Fritz C. Offner, et al.
Glofitamab is a T-cell-engaging, bispecific, full-length antibody. It allows bivalent binding to CD20 (B-cells), and monovalent binding to CD3 (T-cells). The study authors demonstrated with updated data for glofitamab monotherapy step-up dosing higher preliminary response rates than previously reported in patients with R/R NHL who have failed multiple lines of therapy. Cytokine release syndrome was mostly manageable, of low grade, and confined to the first cycle of treatment. Clinical trial information: NCT03075696
L Elizabeth Budde, Nilanjan Ghosh, Julio C. Chavez, et al.
The study authors show with their data, that M-Pola has an acceptable safety profile, with no Gr ≥2 cytokine release syndrome observed. It has promising efficacy in patients with R/R NHL with predominantly aggressive disease. Clinical trial information: NCT03671018